Endocrine Abstracts

Introduction: Secondary hyperthyroidism due to thyrotropin-secreting pituitary adenoma (TSHoma) is rare. Coexistence of TSHoma and primary thyroid disease that could lead to hyperthyroidism is even more unusual.Case report: A 28-year-old female with longstanding and worsening symptoms of hyperthyroidism was admitted to the hospital. Free-T4 (32.89 pmol/l) and free-T3 (6.38 pg/ml) were elevated with moderately increased TSH level (5....

Objective: The aim of the study was to examine characteristics and treatment patterns of Polish acromegalic patients.Methods: A retrospective database analysis was conducted. Adult acromegalic patients treated medically for ≥1 year including at least three injections of lanreotide AUTOGEL 120 were recruited in 36 centres between 29/10/2010 and 31/03/2012. Descriptive analysis was performed to describe demographic and clinical characteristics, treat...

Aim: To evaluate the usefulness of measuring maternal anti-TSH receptor antibodies (TRAbs) and fetal ultrasound (US) monitoring in cases of current or past maternal hyperthyroidism.Materials and methods: A 77 pregnant women with active hyperthyroidism irrespective of its cause or with history of Graves’ hyperthyroidism were observed prospectively. Maternal serum TSH, fT4, fT3, TRAbs, and fetal US were performed at baseline and ...

Introduction: Data regarding the thyroid gland evaluation in Polish adolescents are limited.Aim: The aim of the study was to asses TSH and anti-thyroid peroxidase antibodies (anti-TPO) concentrations as well as thyroid morphology on ultrasound in Warsaw adolescents in regard of family history of thyroid disease.Materials and methods: The study was carried out on a group of 480 adolescents (285 girls and 195 boys), aged 17–18 y...

Background: Primary aldosteronism constitutes the most common form of hormonal hypertension. However, it is often mistreated and widely underdiagnosed. Despite the great progress in laboratory technics of adrenal diseases, in the field of primary aldosteronism there is still a need for novel biomarkers that would clarify the diagnosis in equivocal cases. Adropin is a newly discovered protein that may play a role in glucose metabolism and the development of cardiovascular disea...

Primary hypophysitis (PH) is a rare clinical entity usually presenting with headaches, pituitary deficiency, visual field defects and exceptionally with symptoms of cavernous sinus infiltration such as cranial nerve palsies. An internal carotid artery (ICA) occlusion is unusual complication of PH infiltrating the cavernous sinus. A 32-year old woman presented with a 4-year history of recurring headaches, right retro-orbital pain, periodic diplopia and secondary adren...

Background: Primary aldosteronism (PA) is the most frequent cause of hormonal hypertension, typically associated with hypokalaemia. Whereas hypertension with no hypokalaemia can be present in even half of cases, hypokaleamia in normotensive patients is a very rare finding. Mechanisms that act against developing hypertension despite aldosterone excess are at least a few. Some patients with previous low blood pressure increase its values because of hyperaldosteronism, thus still...

Introduction: Impaired glucose tolerance and overt diabetes mellitus are frequently associated with acromegaly. The aim of this study was to find whether these alterations could be reversed after transsphenoidal surgery.Patients and methods: Two hundred and thirty-nine acromegalic patients were studied before and 6–12 months after transsphenoidal surgery. Diagnosis of active acromegaly was established on the basis of widely recognized criteria. In e...

Diagnostic procedures reveal that majority of incidentally found adrenal tumours (adrenal incidentalomas, AI) appear to be benign adenomas. However, AI accompanying malignant tumours must be diagnosed very carefully to take a proper decision concerning their management. In the registry of the Department of Endocrinology in Warsaw, there are 1888 patients (1388 women, 500 men, F/M ratio 2.8) with AI, 10–87 years old. Primary malignant tumours were diagnosed in 155 patients...

Introduction: Transsphenoidal adenomectomy is the treatment of choice in secreting pituitary adenomas with the symptoms of Cushing’s disease, acromegaly as well as few cases of Prolactinoma, which – due to resistance to pharmacological treatment – require surgery. The efficacy of selective adenomectomy ranges from 60 to 95%. It is the highest in patients with well-visualized by MRI microadenomas, lower in macroadenomas and the lowest when the surgery was ...